There is a clear demand based on the literature for improvements in the designed digital health interventions for palliative cancer care on the basis of all stakeholder needs. A recent review of digital health interventions across multiple diseases found that usability from the physician's side was assessed in only 33% of studies. MyPal is a collaborative H2020 research project aiming to use eHealth technologies in order to support palliative care for cancer patients and healthcare professionals (HCPs), via the adoption of the electronic Patient Reported Outcomes (ePRO) paradigm. The MyPal platform includes an HCP web application, with various modules to support the HCPs, where mainly ePRO data collected from patients are presented in an interactive dashboard via data-intensive visual analytics. The presented study’s primary objective was to evaluate HCPs' perception of usability and satisfaction with the use of the HCP web app, and overall experience of using the system during the RCT in parallel with their routine obligations via standardized quantitative questionnaires after sustained use of a digital health intervention using this web application. This study offers insights into physician satisfaction, preferences, and perceptions of the MyPal HCP web platform. Based on the participants’ feedback, the MyPal HCP web platform is accepted in terms of usability, and noticeably the system’s usefulness is highlighted by all participants' responses. The satisfaction levels of the individual features of the platform are also acceptable. Although in terms of usability the web application is relatively well accepted, it should be noted that bug fixes were sometimes necessary, and this could significantly affect the user experience evaluation. Moreover, based on the answers provided to the open-ended questions some extra features would also be useful.