Artificial intelligence (AI) has great potential to transform healthcare, making it more efficient, equitable, and safe. There are hundreds of AI-based tools available on the market today, yet few get adopted into clinical practice because of numerous barriers and challenges. To explore these barriers and challenges, we reviewed literature on AI adoption in healthcare settings; we interviewed clinicians, healthcare administrators, researchers, non-clinical healthcare staff, and AI manufacturers; and we conducted an international workshop with stakeholders who have experience with the process of trying to adopt AI-based tools into clinical practice. Our research resulted in 26 considerations targeted towards the adopters of AI-based tools, meaning users and buyers of these tools such as healthcare administrators, clinicians, researchers, and other healthcare staff (e.g., procurement, legal, and IT specialists). We believe that as the barriers and challenges to AI adoption are addressed and overcome, AI will inevitably have a lasting impact on improving healthcare for all.