Poster can be found in location 48.

Each year, about 21,000 persons suffer a stroke in Sweden, with one in six between 20 and 64 years of age. Post-stroke fatigue (PSF) is a life-limiting condition, identified as one of the most challenging impairments to manage in everyday life. When planning rehabilitation to promote health after a stroke, it is crucial to acknowledge the person as an expert in their everyday life. However, few studies have focused on the role of work as an integral part of everyday life post-stroke and there is a need to expand the existing knowledge base on PSF and everyday life using larger sample sizes. This study investigated PSF, its development over time, and its impact on return to work and other everyday life activities. In addition, whether PSF could predict functioning in everyday life activities one year post-stroke was investigated. This prospective registry-based study included 2850 patients between 18 to 63 years of age registered in the Swedish Stroke Register during 2017 and 2018. Data were analyzed at 3- and 12-month post-stroke. Three months post-stroke, 43% self-reported fatigue, at 12-months the proportion increased to 48%. Dependence in complex activities one year post-stroke was significantly associated with fatigue. The absence of fatigue one year after stroke was a predictor for positive functioning in everyday activities, increasing the chance of returning to work (OR = 3.7) and to pre-stroke life everyday activities (OR = 5.7). Post-stroke fatigue is a crucial determinant of functioning in complex activities in everyday life. Since PSF persists or increases during the first year post-stroke, it is important for rehabilitation professionals to regularly assess PSF and functioning in everyday life after discharge and allow for the initiation or resumption of rehabilitation measures. Further, interventions addressing PSF are needed to increase the chance of returning to everyday life, including work.