Background: Maternal immunization is underutilized as an approach to prevent maternal and neonatal mortality and morbidity from infectious diseases. The COVID-19 pandemic highlighted how important person-centered vaccine information and communication is to help address vaccine confidence in pregnancy. Understanding parental preferences regarding vaccination conversations with their healthcare providers is key to designing a person-centered intervention to improve vaccine confidence and uptake to protect moms and babies from vaccine-preventable infectious diseases. Methods: Two patient partners trained in Patient and Community Engagement Research (PaCER) recruited fourteen participants for online focus groups (n=4) and in-depth individual interviews (n=4) to understand parental preferences regarding vaccine conversations in pregnancy. Participants were from Canada and self-identified as either preparing for pregnancy, pregnant, postpartum, or breastfeeding. Data was analyzed deductively using thematic analysis. Results: Four themes were identified: 1. Communication Approach: Participants preferred a participatory communication approach during vaccine conversation in pregnancy reassuring their autonomy while receiving guidance to facilitate decision making. 2. Provider Relationship: Trust in their health care provider was more important to participants than the providers’ profession. 3. Conversation Timing: Participants emphasized the importance of discussing vaccines early and often, allowing them time to reflect and discuss options with their partners before making decisions. 4. General Vaccine Conversation Experiences: Participants stressed mutual respect and the absence of coercion as crucial. They asked for empathetic consideration of their circumstances, concerns and values as well as information overload. Participants pointed out that what might feel like a routine discussion for a healthcare provider can be overwhelming to a parent, especially to a first-time parent. Conclusion: Pregnancy is a unique experience and even individuals who self-identify as vaccine-confident can experience decisional conflict when pregnant. Understanding the preferences of parents regarding vaccine conversations during pregnancy is indispensable in co-designing person-centred interventions to improve care and save lives.