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The aging trend, high hospitalization rates, multiple chronic illnesses, and increased vulnerability of hospitalized older people require a person-centered approach to healthcare, an approach that values a person's participation in the healthcare relationship, supports shared decision-making and mutual understanding, and respects a person's values, preferences, and beliefs. However, its implementation and development are still challenging for various health systems and professionals worldwide. The implementation strategy must be based on each country's health system organization, practice contexts, and professionals involved. This work aims to provide guidelines to understand the state of development of person-centered practice (PCP) in the daily care of hospitalized older adults with chronic illnesses within an internal medicine department of a Portuguese hospital. We focus on characterizing the perceptions of a multidisciplinary team working at an inpatient hospital department of PCP; the perceptions of hospitalized older adults with chronic illnesses about PCP; the work culture of an inpatient hospital department with a high prevalence of older adults with chronic illnesses; the PCP Framework at the organizational and structural levels of the healthcare system, and the elements that influence the implementation of PCP at this context. Therefore, a mixed-methods analysis with a convergent design was planned, and data will be collected in parallel and independently from distinct samples of health professionals and older inpatient adults within this department. Furthermore, health policies and strategic plans will be analyzed to identify guidelines for PCP. Studying the clinical practice dimensions in this healthcare context following the PCP Framework can allow us to understand the extent of its development in terms of prerequisites, care environment, care processes, and the macro-context healthcare system. Thus, we might identify and characterize the dimensions achieved and those requiring improvement and establish a starting point for defining strategies to advance practice toward person-centeredness and monitor changes in practice. Keywords:  aged; chronic disease; inpatients; multimethod studies; patient-centered care.