Background: The growing demand for culturally congruent, person-centred care has led to increasing importance of implementation and evaluation of cultural competence interventions across healthcare settings. While evidence indicates that healthcare professionals’ cultural competence can reduce racism and healthcare inequalities, as well as improving their capacity to navigate cultural diversity, a gap remains in summarised evidence regarding its impact on patient-related outcomes. Aim: This systematic review aims to assess the effectiveness of cultural competence interventions on patient-related outcomes. Design: A systematic review was conducted. Methods: A comprehensive search was conducted in MEDLINE, Embase, CINAHL, PsychINFO, ERIC, Web of Science and CENTRAL up to September 2023 for studies using a quasi-experimental or experimental design. Two researchers independently assessed the eligibility of the studies and their methodological quality. The quality of experimental studies was assessed using the Revised Cochrane Risk of Bias Assessment Tool for Randomized Trials (RoB 2), and the quality of quasi-experimental studies with the Risk of Bias in Nonrandomized Studies – of Interventions tool (ROBINS-I). Results: Three studies met the inclusion criteria: one randomised controlled trial and two pre-test/post-test studies. The interventions included educational and training activities (e.g., presentations, group discussions and reflective exercises) or technology-based resources (e.g., online databases). Two studies reported on patient satisfaction, finding no significant difference after implemented intervention. One study, assessing the effectiveness of a combination of offline and online training courses reported a significant difference in on client-nurse trust and satisfaction with nursing care. Conclusion: Despite the growing interest in and research on cultural competence in nursing, this review reveals a substantial gap in the literature addressing the effects of such interventions on patient-related outcomes. This review highlights the urgent need for future empirical research focusing on patient perceptions and experiences within interventions aimed at fostering culturally competent, person-centred care.