Background Currently, most fall-prevention exercise programmes are highly structured and often struggle to maintain participants’ adherence. The Lifestyle-integrated Functional Exercise (LiFE) programme and its modified versions have emerged as alternative interventions, offering advantages in time flexibility and long-term adherence. This systematic review aims to synthesis the effectiveness of LiFE and its modified versions on fall prevention and risk reduction. It also synthesis qualitative and quantitative evidence on their feasibility and acceptability as fall prevention intervention programmes among community-based older adults. Methods Studies that implemented the LiFE programme or its modified versions as interventions in community-based settings and were published in English or Chinese were included. No restrictions were applied to study design. Abstract-only papers and thesis were excluded. Studies reporting fall-related or proxy outcomes were eligible for inclusion. Six databases were searched from inception to May 2025. The Cochrane Risk of Bias (RoB 2) tool and the Joanna Briggs Institute (JBI) Critical Appraisal Tools were used for quality assessment. Meta-analysis and forest plots were applied to examine the effectiveness of falls reduction, while descriptive thematic analysis was used to synthesis data on feasibility and acceptability.   Results A total of 13 studies were included, comprising 547 participants from RCTs and 141 from non-RCTs. The included studies consisted of four RCTs, three single-arm feasibility studies, two mixed-methods studies with single-arm feasibility designs, and two qualitative studies. Preliminary outcomes showed LiFE and its modified versions demonstrated improvements in fall reduction, balance, strength, and quality of life. Participants reported positive experiences; nevertheless, barriers such as paperwork burden and health-related issues (e.g., knee pain) were frequently mentioned. Discussion The findings suggest that more RCTs with long-term follow-up are needed to strengthen the evidence base. Future studies should also include more diverse ethnic groups to enhance the generalisability of the findings.