Background:  The Swedish national knowledge governance system is designed to ensure evidence-based knowledge is used to provide equitable, high-quality care. The system is organised so that national programme areas develop guidance which regional and local levels adapt and implement. In Uppsala County, a need was identified for a local structure that could uphold a system perspective while supporting the introduction of person-centred practices across the care continuum. This led to the establishment of the Local Collaboration Group (LSG) for person-centred practice in 2024.Organisation:  The LSG includes representatives from the county’s two hospitals, primary care, municipal health and social care, disability rights organisations, and the Health and Medical Care Department of Region Uppsala. The group is part of the regional knowledge governance system and promotes a shared, coherent approach to person-centred practice.Working Methods:  The LSG focuses on several areas linked to person-centredness: strengthening family and next-of-kin perspectives; implementing documented mutual agreements; supporting collaboration through Coordinated Individual Plans (SIP); and developing Living Libraries for citizen involvement. The group also supports regional and local bodies when person-centred and coherent care pathways are introduced.System Level and Function:  The LSG operates mainly at the macro level, with attention to system structure, coordination and governance. Its work clarifies responsibilities, improves collaboration and creates better conditions for person-centred practice at the meso and micro levels, where encounters with citizens take place. The group’s broad representation contributes to a more coherent system view and strengthens local implementation efforts.Conclusion:  Uppsala County has chosen to establish a local collaboration group to support person-centred practice, even though this structure is not included in the national knowledge governance system. The initiative provides a clear local point of coordination and contributes to more consistent, long-term support for person-centred work across different levels of the healthcare system.