Dataspace4Health (DS4H) in Luxembourg provides a compelling example of how countries can prepare for large-scale implementation of the European Health Data Space. Focused on real-world use cases in diabetes and cancer, the initiative illustrates how secure, GDPR-compliant data-sharing ecosystems can enhance patient care and support innovative research. With contributions from partners such as NTT DATA, Hôpitaux Robert Schuman, the University of Luxembourg, and the Luxembourg Institute of Health, DS4H addresses critical challenges in interoperability, governance, and trust while leveraging federated infrastructure principles. This lecture will highlight Luxembourg's current progress in piloting primary and secondary data use, aiming to simplify data journeys and thus accelerate research for complex clinical cases. Attendees will learn practical strategies for building connected health data ecosystems and gain valuable insights for stakeholders navigating similar readiness efforts.