A multimodual garment with integrated sensors was previously developed by the multidisciplinary wearITmed consortium including a close collaboration between researchers from medicine, engineering, textile and material science. The sensor garment with multiple integrated sensors (including accelerometers, gyroscopes, optical sensors and textile electrodes) can be used for continuous monitoring of movements and physiologically related variables (e.g. pulse, heart rate variability and changes in blood pressure) which is of great interest in neurological diseases. The garment was developed with a large focus on meeting the needs of professionals and patients’ while maintaining ease-of-use and technical stability. Epilepsy, Parkinson’s disease (PD) and stroke are neurological conditions that are a major cause of long-term disability and mortality worldwide. Effects of treatment and rehabilitation on people with epilepsy, PD or stroke are usually followed through repeated clinical visits, with long term intervals, which can only provide discrete snapshots of symptoms. Objective monitoring of movements and physiological variables using sensors would allow capture of changes and variation over a longer time period for symptoms in epilepsy, PD or stroke. The latest prototype of the garment is recently improved with both technical and practical features to enhance the clinical utility for long-term use by people with epilepsy, PD or stroke. Technical stability was assessed and improved in order to enable the integration of multiple modalities, as well as washability tested through repeated washing cycles. The garment design was also further improved, since comfort and fit are determinant features for long-term use addressed by both patients and professionals.