Background: The Person-centred Practice Framework (PCPF) is a widely adopted model guiding person-centred healthcare delivery (McCance & McCormack, 2021). Despite its conceptual strength, few studies have rigorously examined the framework’s internal structure or tested the relationships among its constructs. Aim: This study explores the internal coherence of the PCPF, focusing on inter-construct and inter-domain relationships within its three core domains—Prerequisites, Practice Environment, and Person-centred Processes—across multilingual and multicultural settings. Methods: A secondary dataset (N=3773) was collated from eight studies using the Person-centred Practice Inventory – Staff (PCPI-S), translated into six languages and spanning seven countries. Bayesian correlation and structural equation modelling (SEM) were used to examine construct-level and domain-level relationships. Confirmatory factor analysis was conducted to test the theoretical structure of the PCPF across language groups. Results: Bayesian correlation analysis showed strong intra-domain and moderate to strong inter-domain construct correlations (Tyagi et al 2025). Structural equation modelling demonstrated excellent model fit (RMSEA=0.047, SRMR=0.057) and confirmed that the Prerequisites domain significantly predicts both the Practice Environment (β = 0.67, p < 0.001) and Person-centred Processes (β = 0.80, p < 0.001). Surprisingly, the Practice Environment did not significantly predict Person-centred Processes. These findings underscore the foundational role of practitioner attributes and highlight the mediating (but not direct) influence of environmental conditions. Conclusion: This is the most comprehensive empirical test of the PCPF to date. The findings reinforce its internal logic, confirm cross-cultural validity, and offer robust evidence to support its use in education, workforce development, and policy implementation. Importantly, the study advocates for dual investment in both staff development and organisational environments to meaningfully embed person-centredness in healthcare systems globally. References: McCance, T., McCormack, B., 2021. The person-centred practice framework. In: McCormack, B., McCance, T., Martin, S., McMillan, A., Bulley, C. (Eds.), Fundamentals of Person-Centred Healthcare Practice, vol. 2021. Wiley, Oxford, pp. 23–32. https://www.perlego.com/book/2068078/fundamentals-of-personcentred-healthcare-practice-pdf