Artificial Intelligence (AI) is rapidly transforming healthcare, offering new possibilities for efficiency, personalization, and clinical decision support. However, AI raises profound questions about ethics, depersonalization, and the preservation of humanistic values in care. This communication critically examines the intersection of AI and person-centred practices using the Person-Centred Practice Framework (PCPF) as an analytic lens. Each domain of the PCPF was explored in relation to emerging evidence on AI integration in health systems. At the Macro Context, AI has the potential to reduce inequities and improve resource allocation, but policies often prioritize efficiency over dignity, and relational care. Within the Prerequisites domain, AI can enhance professional competence through data-driven insights and training, yet it challenges practitioners to retain empathy, ethical clarity, and self-awareness. In The Practice Environment, AI offers opportunities for workload optimization and decision support, but risks eroding collaboration and autonomy if imposed without consultation or transparency. Most critically, within Person-Centred Processes, AI can support personalization and shared decision-making, yet it cannot replicate authentic presence, empathy, or holistic understanding. The relational depth of care remains a uniquely human responsibility. Outcomes associated with AI adoption must therefore move beyond biomedical indicators to incorporate person-reported experiences, dignity, and participation. This reflection concludes that AI can strengthen person-centred practices if guided by values of equity, inclusivity, and relational ethics. However, without intentional alignment to person-centred principles, AI risks reinforcing technocratic and depersonalized models of care. The challenge is not whether AI will be used in healthcare, but how it will be designed, implemented, and evaluated to ensure that technological innovation amplifies rather than diminishes our shared humanity. In this presentation, we will discuss how AI interacts with each domain of the PCPF, highlighting opportunities and risks, and reflect on how person-centred principles can guide the responsible design and implementation of AI in healthcare.