Background: People are living longer with several chronic illnesses and polypharmacy. Polypharmacy affects older persons through increased risk for side-effects, cognitive/physical impairment, and hospital admissions. Frailty exacerbates these risks. The Living with Medicines Questionnaire (LMQ-3) is a person-centred measure of experienced use of medicines and related burden. Investigating such burden can inform interventions to reduce risk and improve medicine usage in a person-centred manner. Aim: To evaluate medicine burden and its relationship with demographic and disease-specific variables in frail older people who have sought emergency care without being hospitalised. Method: RCT baseline data from 217 frail elderly in Sweden who completed the LMQ-3 (41 questions, 8 domains, and a score-range from 45 to 205, (higher score ­­à higher burden)). Descriptive statistics, t-tests, ANOVA and multiple linear regression identified relationships between medicine burden, demographics, frailty, and diseases (p ​​<0.05). 6-month data under collection. Results: 155 patients (71 %) reported a mean total burden of 90.8 (minimal burden). Participants represented FRESH frailty grades: Grade II 45.2%, Grade III 32.3%, and Grade IV 22.6%. A relationship was found between frailty (p<0.001), lung disease (p=0.03,) and total burden. No statistical significance was found regarding burden and age, gender, or education. However, there were statistically significance between these variables and certain domains. No significance was observed for other disease states. Statistically significance was shown between total burden score and domains for ‘impact on everyday life’, ‘concerns’, and ‘side-effects’. Regression analyses showed that frailty Grade IV positively affected the total burden (p ≤0.001). Gender, age, education, and background showed no correlation with total burden. Conclusion: Medicine burden among frail older people who visited the emergency department is minimal to moderate and increases as frailty increases. The domains of impact on daily life, concerns and side-effects contribute significantly to the burden, highlighting the need for person-centered care.