The Clinical Leads Program at Prince of Wales Hospital is a strategic initiative within the hospital’s Quality Safety Culture Framework, designed to enhance person-centred care practices by engaging clinical nurses to collaborate on quality improvement in eight domains of clinical practice, aligning with National Standards. The program cultivates future nursing leaders, builds workforce capability, and fosters a culture of safety, quality, and continuous improvement. Its three core objectives are: to improve person-centred approaches to patient safety outcomes and reduce hospital-acquired complications (HACs); to enhance the capacity and capability of frontline clinical nurses in quality improvement and risk management; to empower Clinical Nurse Leaders to lead quality improvement and research, while mentoring junior staff and modelling best practice. In 2025, the program evolved to include a robust governance structure, with executive sponsors assigned to each clinical domain and a structured educational framework. Quarterly workshops, facilitated by the Expert Facilitators, guide and mentor Clinical Leads through domain-specific data analysis, innovative project design implementation, evaluation and peer education. This structure ensures alignment with hospital priorities and supports sustained, evidence-informed improvements in clinical practice and person-centred care. Over 100 nurse-led ward-level quality improvement projects have been completed to date. These projects are informed by ward culture maps and developed collaboratively by clinicians, ensuring clinical relevance and ownership. Initiatives range from educational innovations, visual communication tools such as posters through to partnering with families in developing personalised delivery of care. The program has fostered strong interdisciplinary collaboration, and many projects have been identified for transferability and scalability, amplifying their impact hospital-wide. This presentation will share insights from the program’s evolution, highlighting how structured leadership development and governance can embed person-centred care processes across complex health systems. Practical strategies for replication and scalability will be discussed.