Improving the health and wellbeing of Aboriginal and Torres Strait Islander peoples in Australia requires a systemic transformation in nursing education—one that privileges Indigenous knowledges, person-centred care, and cultural safety. This presentation shares a transformative curriculum approach that supports this goal by embedding Indigenous-led knowledges and culturally safe pedagogies across all years of nursing education. Despite national accreditation requirements mandating Aboriginal and Torres Strait Islander health content, many institutions continue to rely on isolated units rather than holistic integration. At the Sydney Nursing School, we are addressing this gap through the co-design and implementation of an Integrated Indigenous and Person-Centred Theory (IIPCT) and its companion Curriculum Framework (IIPCCF). These innovations serve as culturally responsive mechanisms to shift paradigms in nursing education. We will present the IIPCT’s philosophical and theoretical foundations and describe how the IIPCCF operationalises these principles throughout the curriculum. This includes how these frameworks advance student capability in cultural safety, relational accountability, and Indigenous governance in education and health. We will discuss the pedagogical and institutional challenges of this work, and highlight how this approach is equipping future nurses to be leaders in equity-focused and culturally safe care. We will particularly focus on the pedagogical challenges posed by introducing this new theory and the culture change needed to operationalise it in teaching practices. We will highlight the theory-informed strategies we are using to prepare nurses who will be leaders in developing sustainable practices to reduce health inequities  and improve the wellbeing of all persons.