Background: Globally person-centredness is increasingly recognised as a critical component of healthcare quality and safety. However, the relationship between person-centred practice and patient safety remains underexplored, particularly in acute care settings. This doctoral study aims to address this gap. Aim: To explore the relationship between person-centredness and patient safety in an acute hospital setting, focusing on the role of evidence, facilitation, and workplace culture. Methods: A case study design was used across three clinical units including surgical, medical and rehabilitation at Prince of Wales Hospital, Sydney. Data collection included ethnographic observations using the Workplace Culture Critical Analysis Tool (WCCAT-R), analysis of existing datasets such as Safety Attitudes Questionnaire (SAQ) findings, person-centred KPIs, quality and safety metrics (e.g. Hospital Acquired Infections), nursing workforce data (e.g. turnover) and semi-structured interviews and focus groups with nursing staff. Descriptive statistics were used to analyse quantitative data and thematic analysis used to analyse qualitative data. These data were then combined for each unit and a cross-case comparison was undertaken. Outcomes: This doctoral study enabled cross-case comparisons to identify contextual factors influencing person-centred care and patient safety. Key findings will highlight common and contrasting processes that support person-centredness, including approaches to engaging with the whole person, understanding and managing risk, and preventing harm. The role of leadership, environmental conditions, and relational dynamics in shaping safety outcomes will be explored. Additionally, the presentation will highlight the types of evidence that engage nurses in evaluating person-centred practice and the facilitation strategies that drive change. These insights offer practical guidance for enhancing person-centred care quality and safety across diverse clinical contexts. Conclusion: The findings of the research will be of international interest to clinicians, managers, researchers, and policy makers and will inform future models of care and organisational strategies aimed at embedding safe person-centred cultures in acute healthcare environments.