Sickle cell disease (SCD) is a hematologic disease associated with decreased life expectancy. SCD comes with vaso-occlusion in the blood vessels, causing extremely painful vaso-occlusive crises (VOCs) which are the main reason for emergency room visits among persons with SCD. Earlier care-seeking and timely treatment are associated with better outcomes. Still, this patient group receive treatment later than patients with other pain conditions due to poor understanding among healthcare professionals (HCPs) regarding SCD and the contrast between chronic and acute pain. In combination with these barriers, there are also preconceptions and stigma when HCPs prescribe opioids. It is important to have patient grounded clinical guidelines and effective interventions to manage e.g. VOCs as well as for better personal treatment. The aim of this study was to explore what has been done to improve ED experiences for people with SCD, and to find knowledge gaps for further research. To meet the aim a review of the scientific literature was conducted. The extension for scoping reviews (PRISMA-ScR) from the Preferred Reporting Items for Systematic Reviews and Meta-Analyses was used as a checklist for the study. To capture the different components from the articles, and to include the frequency of the phenomena, a manifest qualitative content analysis was used. By examining the barriers and interventions related to personalized care, as well as strategies to enhance knowledge, this study contributes to a deeper understanding of how people with SCD can receive more equitable and respectful treatment in EDs. It emphasizes the importance of educating healthcare professionals to foster greater insight into the everyday lives of people with SCD, thereby mitigating negative attitudes and improving personal treatment.